From electrons to cancer : Redox shift as a driving force of tumorigenesis

From electrons to cancer : Redox shift as a driving force of tumorigenesis

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Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available.Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions.A lower click here current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer.The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale.

These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen offworld drum pads to biosynthetic pathways.This new look at cancer may have potential therapeutic applications.